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Longevity Record

The ledger

Grade changes

Grades on this site are computed from recorded study facts, not written — so when the facts change, the grade moves, and the movement lands here automatically. Each entry below was detected by comparing one content build with the next. None of them can be authored by hand, including by us.

  1. 22 August 2026

    NAD+ (direct supplementation): Intravenous NAD+ increases NAD+ availability in the body

    New appraisalEarly

    First published appraisal of this claim. Study links added: PMID 31572171.

  2. 22 August 2026

    NAD+ (direct supplementation): Extends human lifespan or slows ageing

    New appraisalInsufficient

    First published appraisal of this claim.

  3. 22 August 2026

    Fisetin: Clears senescent cells and extends lifespan

    New appraisalPreclinical

    First published appraisal of this claim. Study links added: PMID 30279143.

  4. 22 August 2026

    Fisetin: Improves function or health outcomes in humans

    New appraisalInsufficient

    First published appraisal of this claim.

  5. 22 August 2026

    Coenzyme Q10: Improves outcomes as an adjunct treatment in chronic heart failure

    New appraisalEarly

    First published appraisal of this claim. Study links added: PMID 25282031.

  6. 22 August 2026

    Coenzyme Q10: Combined with selenium, reduces cardiovascular mortality in elderly people with low selenium status

    New appraisalEarly

    First published appraisal of this claim. Study links added: PMID 29641571.

  7. 22 August 2026

    Coenzyme Q10: Slows ageing in healthy adults

    New appraisalInsufficient

    First published appraisal of this claim.

  8. 22 August 2026

    Berberine: Improves blood glucose and lipid markers in people with metabolic dysfunction

    New appraisalEarly

    First published appraisal of this claim. Study links added: PMID 18442638, PMID 40740996.

  9. 22 August 2026

    Berberine: Matches GLP-1 drugs for weight loss

    New appraisalInsufficient

    First published appraisal of this claim.

  10. 22 August 2026

    Curcumin: Reduces knee osteoarthritis pain

    New appraisalEarly

    First published appraisal of this claim. Study links added: PMID 38036015.

  11. 22 August 2026

    Curcumin: Lowers C-reactive protein

    New appraisalEarly

    First published appraisal of this claim. Study links added: PMID 23922235.

  12. 22 August 2026

    Curcumin: Extends human lifespan or slows ageing

    New appraisalInsufficient

    First published appraisal of this claim.

  13. 22 August 2026

    Cold exposure: Activates brown fat and increases cold-induced thermogenesis

    New appraisalEarly

    First published appraisal of this claim. Study links added: PMID 34755128.

  14. 22 August 2026

    Cold exposure: Improves health and wellbeing

    New appraisalInsufficient

    First published appraisal of this claim. Study links added: PMID 39879231.

  15. 22 August 2026

    GLP-1 receptor agonists: Reduces cardiovascular events in adults with overweight or obesity and existing cardiovascular disease

    New appraisalEarly

    First published appraisal of this claim. Study links added: PMID 37952131.

  16. 22 August 2026

    GLP-1 receptor agonists: Produces substantial weight loss in adults with obesity

    New appraisalEarly

    First published appraisal of this claim. Study links added: PMID 33567185.

  17. 22 August 2026

    GLP-1 receptor agonists: Extends human lifespan

    New appraisalInsufficient

    First published appraisal of this claim.

  18. 22 August 2026

    Resveratrol: Improves glucose control and insulin sensitivity in people without diabetes

    New appraisalAgainst

    First published appraisal of this claim. Study links added: PMID 24695890.

  19. 22 August 2026

    Resveratrol: Higher resveratrol exposure is associated with lower mortality

    New appraisalInsufficient

    First published appraisal of this claim. Study links added: PMID 24819981.

  20. 22 August 2026

    Resveratrol: Extends human lifespan

    New appraisalInsufficient

    First published appraisal of this claim.

  21. 22 August 2026

    Urolithin A: Improves muscle endurance in older adults

    New appraisalEarly

    First published appraisal of this claim. Study links added: PMID 35050355.

  22. 22 August 2026

    Urolithin A: Improves biomarkers of mitochondrial health

    New appraisalEarly

    First published appraisal of this claim. Study links added: PMID 32694802.

  23. 22 August 2026

    Sleep: Both short and long habitual sleep are associated with higher all-cause mortality

    New appraisalModerate

    First published appraisal of this claim. Study links added: PMID 20469800, PMID 28889101.

  24. 22 August 2026

    Sleep: Deliberately changing sleep improves hard health outcomes

    New appraisalInsufficient

    First published appraisal of this claim.

  25. 22 August 2026

    Aerobic exercise: Regular aerobic activity and higher fitness are associated with markedly lower all-cause mortality

    New appraisalModerate

    First published appraisal of this claim. Study links added: PMID 25082581, PMID 30646252.

  26. 22 August 2026

    Aerobic exercise: A prescribed exercise programme reduces mortality beyond general activity advice

    New appraisalAgainst

    First published appraisal of this claim. Study links added: PMID 33028588.

  27. 22 August 2026

    Collagen peptides: Improves instrument-measured skin elasticity and hydration

    New appraisalModerate

    First published appraisal of this claim. Study links added: PMID 23949208, PMID 24401291, PMID 33742704.

  28. 22 August 2026

    Collagen peptides: Reduces activity-related joint pain

    New appraisalEarly

    First published appraisal of this claim. Study links added: PMID 18416885.

  29. 22 August 2026

    Collagen peptides: Adds to muscle and strength gains from resistance training in elderly men

    New appraisalEarly

    First published appraisal of this claim. Study links added: PMID 26353786.

  30. 22 August 2026

    Collagen peptides: Slows ageing or extends human lifespan

    New appraisalInsufficient

    First published appraisal of this claim.

  31. 22 August 2026

    BPC-157: Accelerates tendon and soft-tissue healing

    New appraisalPreclinical

    First published appraisal of this claim. Study links added: PMID 42542926.

  32. 22 August 2026

    BPC-157: Improves injury recovery in humans

    New appraisalInsufficient

    First published appraisal of this claim. Study links added: PMID 40756949.

  33. 22 August 2026

    GHK-Cu: Regenerates ageing skin

    New appraisalPreclinical

    First published appraisal of this claim. Study links added: PMID 26236730.

  34. 22 August 2026

    Epithalon: Lengthens telomeres

    New appraisalPreclinical

    First published appraisal of this claim. Study links added: PMID 40908429.

  35. 22 August 2026

    Epithalon: Extends human lifespan

    New appraisalEarly

    First published appraisal of this claim. Study links added: PMID 22451889.

Tracking since 22 August 2026. How grades are derived is documented in full in the methodology.